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KMID : 0617219920030010030
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Duksung Bulletin Phamaceutical Sciences
1992 Volume.3 No. 1 p.30 ~ p.36
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Antigastritic and Antiulcerative Action of the Extract of Zingiberis Rhizoma
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Abstract
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The rhizoma of Zingiber officinale has been used as antiemetic, expectorants, stomachache relieving drugs and digestive accelerators. From the observation of antigastritic action of the methanol extract of the rhizoma, it was fractionated with fexane, chloroform, ethyl acetate and butanol, followed by bioassay on antigastritic and antiulcerative activity. The hexane and the chloroform fraction reduced significantly HCI·ethanol induced gastric lesion at the dose of 370 and 210mg/kg, p.o., respectively. On the gastric ulceration and gastric secretion in pylorus-ligated rats, the hexane fraction decrease the volume of gastric secretion and acid output, and also increased pH at the dose of 370 mg/kg, i.d..It showed considerable curative ratio of acetic acid induced ulcer without inhibition of indomethacin induced gastric lesion. The methanol extract showed low acute toxicity with minimum lethal dose of more than 3000mg/kg, p.o. in mice. In comclusion, Zingiberis rhizoma exgibited antigastic and antiulcerative activity which might be attributable to inhibition of gastric secretion. It is revealed that the active component may be present in the hexane fraction.
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